subiculum

Minute-scale periodic sequences in medial entorhinal cortex

The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity to be organized across long durations of experience. While location is known to be encoded by a plethora of spatially tuned cell types in this brain region, little is known about how the activity of entorhinal cells is tied together over time. Among the brain’s most powerful mechanisms for neural coordination are network oscillations, which dynamically synchronize neural activity across circuit elements. In MEC, theta and gamma oscillations provide temporal structure to the neural population activity at subsecond time scales. It remains an open question, however, whether similarly coordination occurs in MEC at behavioural time scales, in the second-to-minute regime. In this talk I will show that MEC activity can be organized into a minute-scale oscillation that entrains nearly the entire cell population, with periods ranging from 10 to 100 seconds. Throughout this ultraslow oscillation, neural activity progresses in periodic and stereotyped sequences. The oscillation sometimes advances uninterruptedly for tens of minutes, transcending epochs of locomotion and immobility. Similar oscillatory sequences were not observed in neighboring parasubiculum or in visual cortex. The ultraslow periodic sequences in MEC may have the potential to couple its neurons and circuits across extended time scales and to serve as a scaffold for processes that unfold at behavioural time scales.

The functional architecture of the human entorhinal-hippocampal circuitry

Cognitive functions like episodic memory require the formation of cohesive representations. Critical for that process is the entorhinal-hippocampal circuitry’s interaction with cortical information streams and the circuitry’s inner communication. With ultra-high field functional imaging we investigated the functional architecture of the human entorhinal-hippocampal circuitry. We identified an organization that is consistent with convergence of information in anterior and lateral entorhinal subregions and the subiculum/CA1 border while keeping a second route specific for scene processing in a posterior-medial entorhinal subregion and the distal subiculum. Our findings agree with information flow along information processing routes which functionally split the entorhinal-hippocampal circuitry along its transversal axis. My talk will demonstrate how ultra-high field imaging in humans can bridge the gap between anatomical and electrophysiological findings in rodents and our understanding of human cognition. Moreover, I will point out the implications that basic research on functional architecture has for cognitive and clinical research perspectives.

Traveling UP states in the post-subiculum reveal an anatomical gradient of intrinsic properties

COSYNE 2023

Parvalbumin interneurons regulate recall of associations and novelty coding by modulating attractor dynamics in ventral subiculum

COSYNE 2025

Characterization of directionally tuned signals in mouse pre- and postsubiculum during passive rotation using high-density probes

Electrophysiological and morphological characterization of two types of VIP-expressing interneurons in the presubiculum and their facilitating responses following optogenetic stimulation of anterior thalamic fibers

Inhibiting the direct inputs from the dorsal subiculum to the retrosplenial cortex impairs spatial memory in the rat

The internal direction signal in medial entorhinal cortex/parasubiculum is qualitatively different from the head direction signal in upstream brain regions

Selective loss of interneurons in the subiculum in a mouse model for mesial temporal lobe epilepsy

Spatial periodic firing in the subiculum of mice

Traveling UP states in the post-subiculum reveal an anatomical gradient of intrinsic properties

Crosstalk between the subiculum and sleep-wake regulation: A preliminary study

FENS Forum 2024

The differential role of the subiculum > hypothalamic paths in diverse contextual fear responses to a live predator and physically harmful events

FENS Forum 2024

Distinct manifold encoding of navigational information in the subiculum and hippocampus

FENS Forum 2024

Imaging population activity of head direction neurons in the presubiculum of freely behaving mice

FENS Forum 2024

Integrative properties of bursting vs. regular firing subiculum neurons investigated via dynamic clamp

FENS Forum 2024