Vitro Models

Cellular Crosstalk in Brain Development, Evolution and Disease

Cellular crosstalk is an essential process during brain development and is influenced by numerous factors, including cell morphology, adhesion, the local extracellular matrix and secreted vesicles. Inspired by mutations associated with neurodevelopmental disorders, we focus on understanding the role of extracellular mechanisms essential for the proper development of the human brain. Therefore, we combine 2D and 3D in vitro human models to better understand the molecular and cellular mechanisms involved in progenitor proliferation and fate, migration and maturation of excitatory and inhibitory neurons during human brain development and tackle the causes of neurodevelopmental disorders.

A VERSATILE TOOLBOX OF HUMAN IPSC-DERIVED MICROGLIA FOR DISEASE MODELLING AND MULTICELLULAR IN VITRO MODELS FOR NEURODEGENERATION DRUG DISCOVERY

FENS Forum 2026

IN VITRO MODELS TO STUDY HYPOXIA-RESISTANCE IN THE NAKED MOLE-RAT

FENS Forum 2026

DEVELOPING HPSC-DERIVED IN VITRO MODELS AS ALTERNATIVES FOR NEURODEVELOPMENTAL TOXICITY SCREENING

FENS Forum 2026

NEUROPROTECTIVE AND IMMUNOMODULATORY EFFECTS OF NEAR-INFRARED PHOTOBIOMODULATION IN IN VITRO MODELS OF HYPOXIC–ISCHEMIC ENCEPHALOPATHY

FENS Forum 2026

Characterisation of a novel NOX2 inhibitor, GSK2795039, using in vitro models of microglial activation

Decoding retinitis pigmentosa: Unveiling PRPF31 mutation effects on human iPSC-derived retinal organoids in vitro models

FENS Forum 2024

Harnessing 3D and 4D in vitro models to deconstruct human neurodisorders

FENS Forum 2024

Towards novel in vitro models of multiple sclerosis: Development of humanized hippocampal mouse slices

FENS Forum 2024