The main objective of the study was to investigate the antidepressant like effect of curcumin in olfactory bulbectomized model of depression of male wistar albino rats through behavior screening tests. Bilateral olfactory bulbectomy was performed with rats anesthetized under ketamine (50 mg/kg/i.p.).Twenty male albino wistar rats, weighing 150–220 gm were randomly allocated into four groups (n=5)- Group A (control), Group B(olfactory bulbectomy;OB), Group C {vehicle (0.9% NS, 10 ml/kg) +olfactory bulbectomy,OB} & Group D {curcumin (40 mg/kg)+ olfactory bulbectomy;OB}.Behaviour screening tests such as Immobility time (IT-s) in Forced swim test (FST),Tail suspension time (TST);Swimming time (SWT-s) and struggling time(ST-s) in FST; Sucrose Consumption; water Consumption and sucrose preference percentage in Sucrose preference test (SFT) were performed. The data were expressed as mean±S.E.M generated. A oneway analysis of variance (ANOVA) was performed for multiple comparisons and post-hoc tests to identify subsequent pair-wise differences. A p<0.05 was considered statistically signficant. All the variables were found to have statistically significant differences (p<0.05) between Group (A vs B) and Group (B vs D) but for Group (C vs D),TST(IT-s) was not significant (P=0.247) . Whereas, all variables were not statistically significant differences (p>0.05) between Group (B vs C) and Group (A vs D) except FST(IT-s) and FST(ST-s)(P=0.061).The results of the present study suggest that the curcumin has antidepressant like effect in olfactory bulbectomized-induced depression model in behavior screening tests.