Astrocytes interact with neurons at a cellular and molecular level, modulating the synaptic formation, maturation, and function. Their unique morphology allows them to contact synaptic structures to sense, process, and respond to incoming signals. Astrocyte activation leads to intracellular calcium-dependent processes that ultimately modulate circuit function and animal behavior. The IP3 receptor type 2 knockout (IP3R2 KO) mouse model lacks calcium elevations upon astrocytic activation and, therefore, is a good model for studying the roles of intracellular calcium signaling in circuit function. In this work, we performed an in vivo electrophysiological analysis of cortico-limbic circuits of the IP3R2 KO model to assess the involvement of astrocytic calcium-signaling in the modulation of neuronal activity in these regions. Specifically, we recorded local field potentials in the dorsal or ventral hippocampi and the prefrontal cortex. We show here a detailed analysis of power activity and synchrony between these networks. Our data suggest a novel involvement of astrocyte calcium-dependent mechanisms in the modulation of neuronal activity and synchrony that might underlie the computation of cognition and mood.