Retinal Ganglion Cell (RGCs) number density is a key feature of retinal specialization for high visual acuity, as seen in retinal foveas or area centralis (ArCe) in mammals. Mice are broadly used as a genetically tractable model of mamalian vision, however no region of high visual acuity was known. Using combinatorial genetics in Brn3cCre; Brn3bCKOAP mice our group previously reported a region of high RGC density, oriented in a temporo-nasal fashion. We report now experiments characterizing ArCe cell types and developmental features. Using sparse AAVFLEXeGFP virus infections in Brn3cCre; Brn3bCKOAP retinas combined with anti-Brn3b and anti AP (Alkaline Phosphatase) imunostainings, we found that the majority of Brn3b+Brn3c+ RGCs belong to the OFF-DS (JamB) and OFF-delta (OFF-sustained) types, with a few instances of midget-like and small bistratified cells. In humans, albinism affects development of the fovea. TyrCj mice carrying a null mutation of the tyrosinase gene are used as a model for albinism. Using TyrCj/Cj; Brn3cCre; Brn3bCKOAP mice and appropriate controls we found that albinism doesn't significantly affect position and density gradient of ArCe RGCs. To explore the developmental timing of ArCe formation, we analyzed retina, SC and LGN of Brn3cCre; Brn3bCKOAP mice at postnatal days P0, P7 and P19. Preliminary data suggests postnatal refinement of ArCe density gradient relative to the rest of the retina.Future experiments will explore ArCe placement relative to mouse ipsi-contra teritories and consequences on visual function of Brn3c+Brn3b+ RGC ablation.Funding : UEFISCDI Grant PN-III-P4-PCE-2021-0333 (DP, AMT & TCB). Intramural Research Program (EB & BB)