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Authors & Affiliations
Adrien Causse, Jonathan Curot, Amaury De Barros, Luc Valton, Marie Denuelle, Jean-Albert Lotterie, Sara Fernandez-Vidal, Timothy Denison, Emmanuel J. Barbeau, Leila Reddy, David Dupret
Abstract
Brain oscillatory dynamics are ubiquitous signatures of operating neural circuits. Multiple oscillations have been described in many neural structures of the rodent brain, being commonly associated with various behaviours, computations, and codes, in the sensory, cognitive, and motor domains. The extent to which such oscillatory organisation of neural activity features the human brain remains elusive. To contribute to such an investigation, here we present ongoing cross-species work where we apply the same intra-cranial multi-channel recording technique and analytical framework to cortical and subcortical regions from the human and rodent brains. We monitored neuronal ensemble spiking and network oscillations in drug-refractory epileptic patients with hybrid electrodes that contain tetrodes, as in behaving rodents. Having extracted oscillatory patterns using empirical mode decomposition, we present our observations about the frequency content of the local field potentials, describing distinct rhythms ranging millisecond to second timescales and relating these to neuronal spiking across wake, rest, and sleep epochs.