In nature, humans and animals are constantly bombarded with sensory information, which needs to be promptly contextualized to elicit the appropriate motor sequences through a process known as sensorimotor transformation. While we begin to understand how sensory information is transformed into motor action, it is still unclear in what way contextual information can modify a given sensorimotor plan. In this project, we investigate this phenomenon by training water restricted mice in a context-dependent multisensory detection task. We developed a behavioural paradigm in which mice are required to detect two sensory stimuli of different modalities. The first stimulus (whisker deflection) is rewarded upon licking in a context-dependent manner, while the second stimulus (auditory tone) is always rewarded upon licking, irrespective of context. In this task, the context is provided by two background auditory noises of different textures that change every block of 20 trials. Upon learning, mice were able to promptly switch their behaviour according to the contextual cue. To investigate the cortical regions required for the execution of this task, we are carrying out optogenetic inactivation screening of the dorsal cortex in VGAT-ChR2 mice. We are also investigating how different subpopulations of excitatory neurons in the cortex are involved in context dependent sensory processing using widefield calcium imaging in mice expressing GCaMP6f selectively in L2/3 excitatory neurons, and in mice expressing jRGECO1a across all cortical layers. With this approach, we hope to begin to understand how contextual and sensory information integrate to guide behaviour in a flexible manner