Aims: Temporal lobe epilepsy is a neurological disorder characterised by the occurrence of spontaneous seizures. Current treatment methods consist of anti-epileptic drugs, resective surgery or neuromodulation each with significant risks and/or side-effects. Responsive neuromodulation could provide a solution by providing spatial and temporal specificity. In this study, we evaluated whether seizures could be detected with a self-designed embedded system and terminated through activation of the WiChR opsin in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy.Methods: Mice were intrahippocampally injected with kainic acid to simulate temporal lobe epilepsy and with the AAV2/7 viral vector to induce expression of WiChr, a blue light sensitive potassium channel opsin, in hippocampal neurons. Intracranial EEG was recorded and processed with an autonomous, embedded system using a low-power microcontroller to detect the seizure via the amplitude correlation metric. Upon detection, a 473nm laser is activated, delivering pulsed optical stimulation through an optrode implanted in the hippocampus.Results: Stimulation with a pulse train of 10Hz, 5ms, 5mW for 90 seconds resulted in a reduced seizure duration as the seizures stop almost instantaneously. These parameters could be further optimised by increasing the stimulation frequency and decreasing the pulse duration to achieve the same suppressive effect for a reduced stimulation energy.Conclusions: In this study, we prove that our embedded system works for seizure detection in the intrahippocampal kainic acid mouse model and that these seizure can be arrested by limited optical stimulation for inhibition of neurons through activation of the WiChR opsin.