The dorsal dentate gyrus (dDG) plays a pivotal role in stress vulnerability and resilience. dDG granule cells interact with various interneuron subtypes, forming a complex local circuit essential for stress processing. Studies have shown differential activity in specific interneuron subtypes in response to stress, impacting coping mechanisms.This study examines the impact of two distinct categories of DG interneurons, chandelier and basket cells, on coping behavior. Ephrin A7 (EphA7) stabilizes synaptic terminals in basket cells, while Neurofascin (NF) facilitates axo-axonic synapse formation of chandelier cells. Both interact with gephyrin, essential for GABAA receptor clustering. Suppressing Gephyrin clustering by manipulating EphA7 and NF disrupts synapse function, impacting interneuron modulation on granule cells. Through the specific targeting of these interneuron populations, this study aims to unravel the mechanisms underlying stress modulation and potentially identify therapeutic interventions for stress-related disorders.Male rats underwent virus injections to induce knockdowns of either NF or EphA7 in the dDG, followed by a comprehensive battery of behavioral tests to assess coping style, and stress-related behavioral profile. Animals were differentiated based on stress coping ability, and then subjected to behavioral profiling to establish vulnerable or resilient tendencies. Preliminary results suggest that the manipulations employed in this study influenced the animals' pre-stress behavioral phenotype. Furthermore, it appears that coping styles play a significant role in determining the animals' behavioral profile after stress exposure. Notably, depending on the coping style exhibited by the animals, different subtypes of interneurons seem to facilitate stress resilience.