ePoster

Free memory recall is preceded by global cortical network of coincident ripple bursting

Sathwik Prathapagiri, Jesus S. Garcia-Salinas, Jaromir Dolezal, Pavel Daniel, Martin Kojan, Lena Jurkovicova, Robert Roman, Cadgas Topcu, Wojciech Fortuna, Monika Sluzewska, Milan Brazdil, Pawel Tabakow, Gregory Worrell, Jan Cimbalnik, Michal Kucewicz
FENS Forum 2024(2024)
Messe Wien Exhibition & Congress Center, Vienna, Austria

Conference

FENS Forum 2024

Messe Wien Exhibition & Congress Center, Vienna, Austria

Resources

Authors & Affiliations

Sathwik Prathapagiri, Jesus S. Garcia-Salinas, Jaromir Dolezal, Pavel Daniel, Martin Kojan, Lena Jurkovicova, Robert Roman, Cadgas Topcu, Wojciech Fortuna, Monika Sluzewska, Milan Brazdil, Pawel Tabakow, Gregory Worrell, Jan Cimbalnik, Michal Kucewicz

Abstract

High-frequency oscillations (HFOs) have commonly been associated with the pathophysiology of epilepsy but recent evidence points to a cognitive role of neural activities in the gamma, ripple and fast ripple frequency bands (60-500Hz). In particular, encoding and recall of memory induces bursts of HFOs at distinct frequency and latency depending on the cortical location. How these local neural assembly activities are globally coordinated across the brain during memory processing remains elusive. Intracranial local field potential recordings from epilepsy patients were used to detect individual HFO bursts during encoding, delay and recall phases of verbal memory tasks probing free and cued recall of common nouns. We found consistent increases in coincident global HFO bursting that preceded vocalization of freely recalled words by 100-600ms reminiscent of the readiness potential latencies. Interestingly, in the cued recall condition, a peak of coincident bursting was detected earlier around the time of cue presentation, dissociating it from motor preparatory activities of word vocalization. During the encoding phase, we observed a notable suppression of the global HFO coincident bursting right before word presentation and significantly more bursting during presentation of the subsequently recalled words, indicating distinct roles in memory encoding and recall processes. Our results show temporally coordinated HFO bursts across a network of cortical areas associated with memory recall. We propose that this global coincident bursting reflects integration of information across multiple cortical regions to retrieve memory traces before recall and following presentation of cue or new stimuli to be successfully encoded.

Unique ID: fens-24/free-memory-recall-preceded-global-cortical-4993b2af