Network hyperexcitability in Alzheimer’s Disease (AD) is claimed to be an important and potentially treatable pathophysiological mechanism. Empirical and modeling studies suggest that functional connectivity (FC) are promising quantitative neurophysiological markers for network hyperexcitability. This study examines how robust FC measures differ between AD patients with and without interictal epileptiform discharges (IEDs). We obtained eyes closed source-level magnetoencephalography recordings from demographically matched biomarker confirmed AD patients in the mild cognitive impairment and dementia stage with (AD+, n = 23) and without (AD-, n = 23) IEDs in the Amsterdam Dementia Cohort. FC was assessed using the Phase Lag Index (PLI) in the theta (4-8 Hz) band and corrected Amplitude Envelope Correlation (AECc) in the alpha (8-13 Hz) and beta (13-25 Hz) bands. Pairwise statistical tests compared global and regional FC between groups, corrected for multiple comparisons. Post-hoc analyses examined FC differences across regions where IEDs were most prevalent (87%).No significant global differences were observed between groups. AD+ exhibited higher beta AECc in the left precentral gyrus and lower theta PLI in the superior and middle frontal gyrus and the calcarine gyrus compared to AD- (Figure 1), although results did not survive multiple comparisons correction. Post-hoc analyses revealed lower left temporal theta PLI in AD+ compared to AD- (t(22) = 2.19, p = .039).FC reflects network hyperexcitability in AD, but the directional change contradict those previously reported in a comparable study. To establish a robust quantitative measure, we will replicate findings in larger cohorts and include novel measures.