Breathing, a quintessential physiological process, has garnered increasing attention for its profound impact on brain function. Recent investigations have established the pivotal role of respiration in orchestrating rhythmic neuronal activity, facilitated by two primary pathways: efferent intracerebral projections from rhythm generators and reafferent inputs via the olfactory pathway. This intricate interplay between respiration and limbic neuronal dynamics has spurred hypotheses regarding the potential role of breathing in supporting the synchronization of limbic circuits.Yet, elucidating the causal relationship between respiratory inputs and observed neuronal synchronization poses a formidable challenge, primarily due to the continuous nature of respiratory inputs to neuronal circuits. To overcome this challenge, we need to be able to hijack the intrinsic pacemakers and control the frequency and timing of breathing. Toward this goal, we established a novel approach to optogenetically control breathing in awake, behaving mice. Through precise manipulation of respiratory frequency, timing, and induction of apnea, we gain unprecedented control over respiratory patterns. This novel approach empowers us to explore neuronal activity under controlled respiratory conditions, shedding light on the impact of respiration on limbic circuit dynamics.Leveraging large-scale electrophysiological recordings from hippocampal, thalamic, and cortical networks, we delineate the functional role of respiration in organizing and coupling neuronal dynamics and functional connectivity within the limbic circuit.