Hippocampal subregion CA2 has been implicated in social memory. CA2 contains spatially modulated “place cells” that change their firing patterns (“remap”) during social interactions (Alexander et al., 2016). Our preliminary results suggest that CA2 place cell remapping is driven by the olfactory content of social experiences. Fragile X Syndrome (FXS) is a neurodevelopmental disorder associated with abnormal social behaviors. To our knowledge, the activity of CA2 place cells during social interactions has not been examined in relation to FXS. Here, we recorded CA2 place cells in wildtype (WT) control rats and in a rat model of FXS (Fmr1 knockout rats or “FXS rats”) during exposure to familiar social odors. Preliminary results suggest that CA2 place cell remapping to social odors does not occur in FXS rats. Prior work showed that CA2 place cells that fire during social exploration of novel conspecifics are reactivated in sharp-wave ripples (SWRs) during subsequent rest (Oliva et al., 2020). We recorded SWRs in CA2 of FXS rats and WT rats during rest periods following exploration of a familiar social odor. We found that CA2 place cells that responded to social odors preferentially increased their firing rates during subsequent SWRs in WT, but not FXS, rats. These results suggest that impairments in CA2 place cells that code social stimuli may contribute to social deficits in FXS.