ePoster

Mouse saccades are cognitive state and task dependent in naturalistic and immersive decision-making tasks

Robert Taylor, Moad El Hay, Cora Wolter, Mina Glukhova, Marieke Scholvinck, Martha Havenith
FENS Forum 2024(2024)
Messe Wien Exhibition & Congress Center, Vienna, Austria

Conference

FENS Forum 2024

Messe Wien Exhibition & Congress Center, Vienna, Austria

Resources

Authors & Affiliations

Robert Taylor, Moad El Hay, Cora Wolter, Mina Glukhova, Marieke Scholvinck, Martha Havenith

Abstract

Goal-directed saccades have been studied extensively in primates. In contrast, eye movements in mice have been thought to mainly coordinate eye-head coupling, rather than actively select visual input, due to the absence of a retinal fovea and their reliance on non-visual senses. But does this hold true during naturalistic behaviour?To study mouse eye movements in a naturalistic context featuring self-initiated visual flow and the need for visual target tracking, we designed a foraging task presented in a virtual reality, projected onto a 210-degree immersive environment (Fig1A). The saccades were identified using DeepLabCut.We show that in this context, mice exhibit saccades responding to visual stimuli (Fig1B) and modulated by cognitive state. Specifically, saccades disappear around stimulus onset (Fig1C), suggesting periods of informative fixation, and increase as animals make choices. Moreover, 'exploratory’ ventral saccades tend to decrease as animals become confident in their stimulus choice, but remain frequent in incorrect trials (Fig1D). These findings demonstrate that under conditions of naturalistic self-motion and visually cued foraging, eye movement patterns in mice reflect stimulus and task processing. This suggests that mice use goal-directed saccades to actively gather behaviourally relevant visual information.Figure 1. A. Diagram of DomeVR setup. B. Raw eye position across the cue and stimulus presentation. Eye trace shown as X and Y coordinate position over time. C. Saccade frequency plot across cue hit, separated by Nasal and Ventral saccades. D. Ventral saccade moving window sums across cue hit.

Unique ID: fens-24/mouse-saccades-cognitive-state-task-dependant-1ea16076