Major depressive disorder (MDD) is a global health concern, displaying a diverse range of symptoms and a recognized association with chronic pain. Current evidence suggests that astrocytes play a key role in both disorders. Consequently, we investigated the effect of olfactory bulbectomy (OBX), a well-known model of depression-related behavior, on nociceptive behaviors and the number and morphology of astrocytes within the basolateral amygdala (BLA) in male rats. We conducted behavioral test, including the von Frey assessment of mechanical allodynia and acetone test of thermal cold allodynia, across three independent groups. The assessment points post-surgery were at one, four and fifteen weeks. To assess astrocytic remodeling and density, we employed quantitative morphological analysis and examining the number of glial fibrillary acidic protein (GFAP) positive cells in the BLA. Our findings indicate that OBX induces mechanical and thermal allodynia during the three post-surgery evaluation periods. One-week post-surgery, OBX increased the number of GFAP positive astrocytes without significant remodeling in the astrocytic processes. At four weeks post-surgery, OBX increased the number of GFAP positive astrocytes coupled with a reduction in total filament length. Fifteen weeks post-surgery, OBX selectively increased the number of GFAP positive astrocytes. This study reveals persistent behavioral indications of allodynia and sustained astrocytic activation within the brain. These results reinforce the connection between pain and depression, supporting the neuroinflammatory hypothesis of MDD.