Social interaction is a fundamental pillar of our society. It has made possible extraordinary achievements such as going to the moon. In humans, a rare autosomal disease characterized by calcification of the basolateral amygdala (BLA), revealed the importance of the BLA and its connections to the medial prefrontal cortex (mPFC) in generous investments. However, the neural mechanisms underlying social interactions that lead to fruitful cooperation remain largely unknown. In this study we address the role of the prosocial neuropeptide oxytocin in neural circuits between the mPFC and the BLA involved in collaboration. Although oxytocin receptors have been found in both regions, its precise location and its effect on social collaboration remain to be determined. Using a transgenic rat line expressing CRE under the oxytocin receptor promoter in combination with viral labeling we found that cells expressing the oxytocin receptor were located throughout the anterior cingulate, prelimbic and infralimbic cortices. In vitro patch clamping recording furthermore showed that action potential firing rate of oxytocin receptor cells increased when an oxytocin agonist was added to the bath. Current work aims to determine whether oxytocin can directly affect neuronal activity of cells projecting from the mPFC to the BLA, suggesting that oxytocin signaling modulates the neuronal circuitry between the mPFC and the amygdala. Furthermore, we implemented a new behavioral task in which two rats must cooperate to obtain food in order to study the social communication behavior of rats and to determine how oxytocin can influence the success of a cooperation.