Objectives: We aim to investigate the impact of acute stroke on delta oscillation in STN and to explore the correlation between motor disability and the altered delta oscillation in STN following stroke. Methods: 10 Sprague-Dawley rat were included in this study. They were trained in single pellet reaching task before stroke induction and motor performance was determined as baseline. STN was recorded before and 30 mins within after stroke. A photothrombotic ischemic lesion ipsilateral to the STN recording site was induced in M1. 3 days after the stroke, we evaluated motor performance using the pellet reaching task. Results: After a stroke, both the delta peak power and mean power significantly decreased in STN. The firing rate significantly declined from 65 spk/s to 15 spk/s in STN during acute stroke. The Spearman's rank correlation coefficient revealed a strong relationship between the decline in delta mean power and the decline in success rate (r = 0.649, p=0.042 ), as well as the increase in attempts (r = 0.823, p=0.003 ) after stroke. Additionally, the decline in delta peak power was strongly associated with to the decline in success rate (r = 0.709, p=0.022 ). Conclusions: Our study indicates that 1) pathological activation of delta oscillation may occur in the STN during acute stroke. 2) The STN experiences a strong inhibition during the acute stroke.3) Following a stroke, more decrease in delta power may indicate greater loss of motor function to acute stroke.