Food odours are perceived before consumption and trigger physiological responses (e.g., appetite, saliva, digestive enzymes) to help the body prepare for ingestion. Importantly, smell perception through the olfactory bulb (OB) increases when hungry. The mechanism linking metabolism and olfaction remains unknown, but there is converging evidence that the olfactory system is a target for metabolic hormones associated with food intake regulation and may adapt the olfactory system to nutritional needs by promoting or inhibiting food-seeking. Here, we looked at the hormone ghrelin as a signal of energy deficit during fasting and its interaction with ghrelin receptors (GHSRs) in the OB.Using a viral approach, we genetically deleted GHSRs specifically in the OB to examine the role of ghrelin signalling in the OB on metabolism, mood, and memory. Results revealed a significant impact on olfactory performance observed in both fed and fasted mice, as well as an increased latency to find food under fasted and ghrelin-induced conditions. Anhedonia was evident in a two-bottle choice assay, as mice lacking GHSRs did not show a preference for saccharin over water. In support of this, anxiety levels were significantly increased, and exploratory locomotor activity was reduced in multiple anxiety behavioural tasks. Despite changes in food-seeking behaviours, food intake remained unchanged. Intriguingly, mice increased body weight, fat mass, and blood glucose, indicative of metabolic dysfunction.We conclude that GHSRs in the OB maintain olfactory sensitivity, influencing several behavioural and metabolic adaptations to help a mammal detect and respond appropriately to food and odour cues.