ePoster

Sexual dimorphism in compulsive alcohol drinking and its impact on pathological gambling and social dominance: A preclinical study

Manuela Olmedo Córdoba, Elena Martín-González, Ángeles Prados-Pardo, Margarita Moreno
FENS Forum 2024(2024)
Messe Wien Exhibition & Congress Center, Vienna, Austria

Conference

FENS Forum 2024

Messe Wien Exhibition & Congress Center, Vienna, Austria

Resources

Authors & Affiliations

Manuela Olmedo Córdoba, Elena Martín-González, Ángeles Prados-Pardo, Margarita Moreno

Abstract

Compulsivity denotes the incapacity to discontinue a persisting behavior that has become inappropriate for the prevailing circumstances. Clinical research indicates a comorbidity between alcohol use disorder and obsessive-compulsive symptomatology, leading to a pattern of compulsive alcohol consumption. Thus, compulsivity may be a vulnerability factor contributing to loss of control and alcohol abuse. The aim of the current study was to assess compulsive alcohol drinking and its implication as a determinant for the development of pathological gambling and social violence in both sexes. To accomplish this, male and female Wistar rats were selected as high (HD), or low (LD) drinkers based on rate of drinking behavior on Schedule-Induced Polydipsia (SIP). Subsequently, the rats were exposed to SIP with alcohol, and diverse groups were formed based on their levels of water and alcohol intake. Following group formation, a series of behavioral tasks were conducted, including the probabilistic spatial reversal learning task, the rodent gambling task, the dominance tube test, and Crawley's sociability test. The outcomes will be discussed, taking into consideration sex differences, in terms of identifying behavioral traits such as cognitive inflexibility, risky decision-making, and social dominance and interaction within a population vulnerable to alcohol drinking. In conclusion, compulsivity stands out as a vulnerability factor in the development of alcohol use disorder, with sexual dimorphism in its development.Funded by PND-2022l024 Plan Nacional sobre Drogas, MISAN, Gobierno de España, and PID2022-139286NB-I00 Proyectos de Generación de Conocimiento, Gobierno de España and FEDER I+D+i funds.

Unique ID: fens-24/sexual-dimorphism-compulsive-alcohol-1b4905bc