Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with social communication deficits, repetitive behaviors, and atypical sensory responses. Around 90% of the patients diagnosed with ASD experience atypical sensory events, with abnormal responses to tactile stimulation. However, the neurological underpinnings of tactile dysfunction in ASD are not yet understood. Using behavior and electrophysiological in vivo recordings, this work aims to promote a better understanding on tactile sensitivity and neuronal responses to glabrous skin tactile stimulation in Shank3 KO mouse model of ASD. Our behavior tests show that Shank3 KO mice exhibit increased repetitive behaviors when exposed to a novel textured surface. In vivo electrophysiological recordings in the hindlimb region of the primary somatosensory cortex (S1HL) show increased firing rates in both spontaneous and tactile-evoked activity, across all cortical layers of Shank3 KO mice, particularly in layer 4 and 5. Since sensory processing is affected by thalamocortical connections, exploratory preliminary data of simultaneous electrophysiological recordings in Shank3 KO of both the S1HL and thalamus while performing glabrous skin hindpaw stimulation will also be presented. Our findings enrich the understanding of tactile dysfunction in ASD, particularly in the Shank3 KO mouse model, potentiating a better understanding of this disorder and how specific symptoms may affect patients differently, representing an opportunity for the development of novel effective therapeutic strategies.