The perinatal phase is critical for offspring development. In this period, a peculiar epigenetic remodeling establishes a parent-of-origin specific expression in a subset of mammalian genes, known as “imprinted”. These genes are pivotal for the placenta, fetal, and brain growth and exert long-lasting effects on the offspring's metabolism and behavior. Recently, also direct and indirect influences of imprinted genes on sleep were identified, but the underlying mechanism remains poorly understood. Perinatally, adequate sleep is vital for the proper formation of the offspring's brain, physiologic functions, and mother-infant bonding.Here, we explored the relationship between sleep and genomic imprinting and how this interplay affects the correct development of a newborn. In murine dams and pups, sleep deprivation (SD) was applied in specific perinatal timeframes corresponding to distinct phases of imprinted genes' epigenetic remodeling. Short- and long-term behavioral and molecular effects were investigated in the offspring. Our analyses in pups suggest that SD affects the emission of separation-induced ultrasonic vocalization and sociability. The behavioral characterization of the adults together with the assessment of their sleep-wake pattern will be integrated with gene expression and methylation profiles characterized in distinct brain areas. Also, by performing these analyses in germinal cells, we will evaluate the potential for transgenerational transmission of alterations.Along with expanding our understanding of sleep–genomic imprinting interplay, this project holds promise for identifying molecular markers tracking sleep deprivation effects across critical developmental phases characterized by specific changes in imprinted genes that, when altered, can determine long-lasting impairments and negative health outcomes.