Ischemic stroke results from neural tissue death due to a decrease in blood supply, and is a major cause of death and motor disabilities worldwide. Although it is established that the tissue immediately surrounding the stroke core undergoes spontaneous functional reorganization, partially taking over lost functionality, the role of the healthy contralesional cortex remains unclear. Adaptions in neuronal activity on the contralesional side have been reported both in humans and in rodent stroke models, but it remains elusive whether such modifications represent spontaneous functional re-mapping rather than maladaptive changes.To investigate this question, we developed a reach-to-grasp task, in which mice manipulate a joystick with their preferred forelimb to receive a reward. Expert mice received a large photothrombotic stroke to the contralateral sensorimotor cortex, followed by weekly assessment of grasping function. We show that the lesion produces impairments in the fine motor control, leading to reduced task performance and changes in forelimb trajectories. Additionally, we observe spontaneous – albeit limited - motor recovery following the stroke.We performed bilateral widefield calcium imaging of cortical activity in mice expressing GCaMP6f under the Thy1 promoter. Simultaneously, we recorded both forelimbs and orofacial movements using high-speed cameras to characterize changes in cortical activity representing skilled forelimb movements, while controlling for correlated behavior. Using GLMs, we fitted behavioral variables to neuronal activity. We observe post-stroke changes in the contralesional representation of both the healthy and impaired limb, and find that the extent of change correlated with the severity of the motor impairment.