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ASTROCYTIC FOXO1 IN HIPPOCAMPUS-DEPENDENT BEHAVIOR MODULATION
Alexandra Veigaand 7 co-authors
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS06-09PM-225
Presentation
Date TBA
Board: PS06-09PM-225
Event Information
Poster Board
PS06-09PM-225
Poster
View posterAbstract
Astrocytes are crucial for modulating synaptic activity and behavior through bidirectional communication with neurons. They sense and respond to neuronal activity by elevating intracellular calcium levels, which display complex spatiotemporal properties. To identify calcium-dependent signaling pathways downstream of astrocytic activity, we studied the IP3 receptor type 2 knockout (IP3R2 KO) mouse model that lacks global calcium elevations in astrocytes. Molecular analysis of hippocampal tissue of this model with impaired calcium-dependent signaling revealed hundreds of up- and down-regulated genes, among which 76 are modulated by the astrocyte-specific transcription factor Foxo1. Given that IP3R2KO mice display altered hippocampus-dependent behaviors, we hypothesized that astrocytic Foxo1 modulates these behavioral phenotypes.
To test this hypothesis, we used viral vectors to overexpress or silence Foxo1 in hippocampal astrocytes. This bidirectional manipulation allowed us to establish astrocytic Foxo1 as a novel regulator of hippocampal circuit function, with implications for mouse behavior.
To test this hypothesis, we used viral vectors to overexpress or silence Foxo1 in hippocampal astrocytes. This bidirectional manipulation allowed us to establish astrocytic Foxo1 as a novel regulator of hippocampal circuit function, with implications for mouse behavior.
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