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BRAIN TEMPERATURE CHANGES DURING EPILEPTIC SEIZURES IN MICE
Ákos Móroczand 4 co-authors
HUN-REN Research Centre for Natural Sciences
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-399
Presentation
Date TBA
Board: PS01-07AM-399
Event Information
Poster Board
PS01-07AM-399
Poster
View posterAbstract
Brain temperature is an important modulator of neural activity. On the other hand, increased cell firing also increases local temperature. Here we examined brain temperature changes during epileptic seizures with a dual-purpose thermoelectrode, suitable for temperature measurement as well as neural recording. To evoke seizures, we utilized an optogenetic acute seizure model. Briefly, a short (15s) stimulation of layer 6 corticothalamic cells in the somatosensory cortex induced an instant tonic-clonic seizure in NTSR1-cre mice. The thermoelectrode had standard electrophysiological recording sites, and a meander for thermoresistive measurements. We found a temperature marked increase (~0.5 °C) during seizures, larger than fluctuations during sleep, but smaller than the difference between sleep and awake states.
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