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ePoster
<EM>C1QTNF4</EM> IS A LOCALLY TRANSLATED MRNA THAT ENCODES THE SECRETORY FACTOR CTRP4 FOR SYNAPSE FORMATION OF HIPPOCAMPAL NEURONS
Xuejun Liand 3 co-authors
City University of Hong Kong
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-174
Presentation
Date TBA
Board: PS01-07AM-174
Event Information
Poster Board
PS01-07AM-174
Poster
View posterAbstract
The complicated neuronal morphology of dendritic arborization and elongated axon demands huge amount of newly synthesized proteins. Local mRNA translation near synapses is also crucial to rapidly adjust the synaptic proteomes in response to stimulation during synaptic plasticity. Previous transcriptomic studies have identified thousands of different mRNAs in dendrites and axons. The key question of whether different mRNAs are transported to distinct sub-dendritic compartments remains largely unexplored. Our unpublished transcriptomic data identified C1qtnf4 as one of the novel mRNAs enriched in the synaptoneurosome. We found that C1qtnf4 mRNA is specifically localized at dendritic spines of hippocampal neurons in response to chemical long-term potentiation (cLTP) and becomes spatially close to the dendritic micro-secretory organelles at the base of dendritic spines. C1qtnf4 encodes the secreted protein CTRP4, which is highly expressed in the brain, yet its neuronal function is poorly understood. Our results show that CTRP4 is locally translated near dendritic spines, and its depletion leads to fewer mushroom spines and excitatory synapses. Our findings therefore demonstrate C1qtnf4 as a synaptically localized mRNA that is translated near the dendritic micro-secretory system organelles to promote synapse development in hippocampal neurons.
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