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CERAMIDE LEVELS ELUCIDATED IN ASTROCYTE REACTIVITY DURING ALZHEIMER'S DISEASE
Anita Lygeroudiand 4 co-authors
Amsterdam UMC, Location Vrije Universiteit Amsterdam
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-197
Presentation
Date TBA
Board: PS05-09AM-197
Event Information
Poster Board
PS05-09AM-197
Poster
View posterAbstract
Alzheimer’s disease (AD) is a fatal neurodegenerative disease with no effective treatment available. Astrocytes are crucial for maintaining brain homeostasis and their dysfunction can propagate AD pathogenesis. Accumulating evidence suggests that reactive astrogliosis occurs early during AD progression and an important role is emerging for altered lipid production and signalling, specifically by sphingolipids, during AD. Ceramides are considered key molecules in the complex sphingolipid biology. They can either contribute to inflammation and cell death or promote pro-survival signalling, depending on their chain-length. Recent studies have indicated that specifically reactive astrocytes are important producers of proapoptotic ceramides in the context of AD. However, the regulation of distinct ceramide species and their biosynthetic enzymes in astrocytes during neuroinflammation remains poorly understood. Here, we focus on the sphingolipid profile of human induced pluripotent stem cell (iPSC)-derived astrocytes, to elucidate the mechanism driving the shift towards more pro-apoptotic ceramides during neuroinflammation. This study will provide fundamental knowledge to better understand disease aetiology and assess whether restoring the sphingolipid balance could serve as a potential therapeutic approach for AD.
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