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CIRCUIT-SPECIFIC ENCODING OF RISK IN THE AMYGDALA AND ASSOCIATED CORTICAL AREAS
Martin Zellerand 2 co-authors
Friedrich Miescher Institute for Biomedical Research
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-112
Presentation
Date TBA
Board: PS02-07PM-112
Event Information
Poster Board
PS02-07PM-112
Poster
View posterAbstract
Economic decision-making under risk is characteristically risk-averse, and accompanied by somatic measures of arousal as well as hesitant motor behaviour. While studies of human patients with focal brain lesions have robustly implicated the amygdala and several cortical areas in generating risk aversion, the precise underlying neuronal activity patterns and circuit mechanisms have remained underexplored. Here, we have developed a novel task for economic decision-making under risk in freely moving mice, during which we record cell-type-specific neuronal activity using calcium imaging, amd monitor somatic arousal via electrocardiogram recordings. Using this approach, we demonstrate behavioral parallels between human and murine decision-making, and provide a survey of neuronal activity in this task across multiple amygdala cell types and cortical regions.
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