Poster preview
ePoster
COGNITIVE REJUVENATION THROUGH PARTIAL REPROGRAMMING OF ENGRAM CELLS
Gabriel Berdugo Vegaand 7 co-authors
EPFL
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-056
Presentation
Date TBA
Board: PS02-07PM-056
Event Information
Poster Board
PS02-07PM-056
Poster
View posterAbstract
Counteracting cognitive decline is a declared goal of regenerative medicine. Recently, partial cellular reprogramming has emerged as a promising strategy to promote tissue regeneration and restore cellular function, but whether this approach bears fruit when targeted to cell populations underlying cognitive processes remains unknown. Here, we report that partial reprogramming of engram neurons – bona fide memory trace cells – by OSK-mediated gene therapy reversed the expression of senescence and disease-related cellular hallmarks in aged mice and models of Alzheimer’s disease (AD), re-established aberrant epigenetic-transcriptional patterns pertaining to synaptic plasticity and counteracted AD-typical neuronal hyperexcitability. Importantly, irrespective of the brain area targeted or the behavioural paradigm employed, engram reprogramming also recovered learning and memory capacities to levels of healthy young animals, suggesting cognitive rejuvenation. These results posit that partial reprogramming of specific cell populations in the brain can be exploited for cognitive restoration in aging and disease.
Recommended posters
PARTIAL REPROGRAMMING OF A GFAP-EXPRESSING SUBPOPULATION IN THE HIPPOCAMPAL SUBGRANULAR ZONE IMPROVES ADULT NEUROGENESIS AND COGNITION IN AGING MICE
Alejandro Anton Fernandez, Marta Roldán Lázaro, Jesús Ávila, Félix Hernández
DECIPHERING PARTIAL REPROGRAMMING MECHANISMS IN MATURE NEURONS: IMPLICATIONS IN HEALTHY AGEING
Irene Rodríguez Navarro, Sofia Zaballa, Alba Ramón, Manuel J Rodríguez, Mercé Massana, Albert Giralt, Daniel Del Toro
IN VIVO PARTIAL REPROGRAMMING TO REGENERATE AGED TISSUES INDUCED BY CHRONIC STRESS
Sara Borràs Pernas, Irene Rodríguez Navarro, Lisa Patterer, Daniel Del Toro, Albert Giralt
TARGETING INTRACELLULAR A-ΒETA OLIGOMERS PROMOTES NEUROGENESIS-DEPENDENT RESCUE OF HIPPOCAMPAL FUNCTION AND MEMORY IN AN ALZHEIMER'S DISEASE MOUSE MODEL
Laura Coppola, Raffaella Scardigli, Elena Fiori, Sofia Mancini, Silvia Middei, Federico La Regina, Giovanni Meli, Antonino Cattaneo
ENGINEERING HIPPOCAMPAL SYNAPTIC CONNECTIONS IN AGED MICE
Songhee Choi, Shin Heun Kim, Sangkyu Lee, Yong Jeong
E2F4-BASED GENE THERAPY RESTORES LONG-TERM POTENTIATION AND MEMORY FORMATION AND BLOCKS NEURONAL DEATH IN AN ALZHEIMER MOUSE MODEL
Cristina Sánchez-Puelles, Alicia Hernández-Vivanco, Alberto Fraj-Cebrián, Vanesa Cano-Daganzo, Gertrudis Perea, José María Frade