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THE DARK SIDE OF ENRICHMENT: ENVIRONMENTAL ENRICHMENT FACILITATES MORPHINE REWARD VIA NEUROINFLAMMATORY PATHWAYS
Jing Yi Panand 2 co-authors
Fo Guang University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS06-09PM-656
Presentation
Date TBA
Board: PS06-09PM-656
Event Information
Poster Board
PS06-09PM-656
Poster
View posterAbstract
Although Environmental Enrichment (EE) is frequently postulated to mitigate drug-seeking behaviors, its specific modulation of opioid reward processing is not fully understood. We challenged the protective hypothesis of EE by housing mice in an enriched environment for 21 days prior to conditioning. Subsequently, a Conditioned Place Preference (CPP) paradigm was employed, using an alternating injection schedule of morphine (10 mg/kg, i.p.) and saline, followed by a standard 15-minute post-conditioning test. While the establishment of morphine-induced CPP was confirmed, our data revealed a paradoxical outcome: rather than attenuating drug preference, EE appeared to potentiate the rewarding effects of morphine. To decipher the neurobiological basis of this unexpected facilitation, we are currently quantifying the expression of BDNF and the pro-inflammatory cytokine IL-1β within the medial prefrontal cortex, amygdala, and hippocampus via immunohistochemistry. These findings highlight a complex interplay between environmental factors and neuroinflammation in the context of addiction.
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