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DECIPHERING PARTIAL REPROGRAMMING MECHANISMS IN MATURE NEURONS: IMPLICATIONS IN HEALTHY AGEING
Irene Rodríguez Navarroand 6 co-authors
1. Biomedicine Department, Faculty of Medicine, Institute of Neuroscience, University of Barcelona, 08036 Barcelona, Spain.
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS03-08AM-332
Presentation
Date TBA
Board: PS03-08AM-332
Event Information
Poster Board
PS03-08AM-332
Poster
View posterAbstract
The discovery of the Yamanaka Factors (YFs)—OCT4, SOX2, KLF4, and MYC—has revolutionized cellular biology by demonstrating their capacity to induce pluripotency, reverse molecular signs of aging, and reprogram somatic cells. While much of the research has focused on peripheral tissue regeneration, the role of YFs in the central nervous system, particularly in the context of aging and healthy aging, remains largely unexplored. Here we use profiling experiments, neuronal assays, and behavioral tests to examine the impact of YFs induction on mature neurons in the cerebral cortex of both young and aged mouse brains. These results could reveal age-related changes driven by partial reprogramming, providing new insights into the mechanisms by which YFs mitigate the effects of aging and highlight their potential for neuronal rejuvenation.
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