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DISSECTING COST-BENEFIT MODULATIONS OF VIGOR DURING FORAGING REVEALS COMPLEMENTARY MOTIVATIONAL FUNCTIONS OF DORSAL AND VENTRAL STRIATUM
Zelda Timmeland 3 co-authors
Aix Marseille University, INSERM U1249
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS06-09PM-628
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Date TBA
Board: PS06-09PM-628
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Poster Board
PS06-09PM-628
Poster
View posterAbstract
Humans and other animals adjust when and how fast they execute goal-directed actions based on expected costs and benefits, yet the behavioral principles and neural processes underlying vigor control remain poorly understood. Here, we developed a self-paced foraging task in which rats ran back and forth on a motorized treadmill, allowing independent manipulation of reward opportunity and motor cost. Across foraging sessions, run frequency and speed covaried with the subjectively perceived urgency to obtain rewards. In contrast, increasing the cost of crossing the treadmill led rats to run faster to maintain their reward rate, while run timing was preserved. Consistent with distinct neural mechanisms underlying vigor modulation by costs versus benefits, lesions of the dorsal striatum selectively impaired running speed under high-effort conditions, whereas lesions of the ventral striatum reduced reward-seeking urgency. Altogether, our findings reveal dissociable modulations of vigor by costs and benefits mediated by distinct striatal regions, with the ventral striatum setting the urgency based on subjective value and the dorsal striatum being implicated in invigoration of movements under high motor costs.
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