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DISTRIBUTION AND FUNCTIONAL SIGNIFICANCE OF RODENT CEREBELLAR GLYCOGEN
Ashley Bomin Leeand 15 co-authors
Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-219
Presentation
Date TBA
Board: PS04-08PM-219
Event Information
Poster Board
PS04-08PM-219
Poster
View posterAbstract
The mammalian brain stores glucose, the main energy substrate from circulation, in the form of glycogen. In rodents, the cerebellum is known to store relatively large amounts of glycogen, yet its cellular and subcellular distribution has not been described in detail. Using monoclonal antibodies for glycogen, we investigated the glycogen distribution in the mouse cerebellar cortex. We found a dominant presence of glycogen in molecular layer Bergmann glia (BG) processes. Additionally, glycogen is observed in Purkinje cells (PCs), the principal neurons. To address the functional significance of cerebellar glycogen, we examined behaviors in mice that lack glycogen synthase 1 (Gys1) in BG or PCs using a Gys1 floxed mouse line. Gys1 deficiency in PCs or GFAP-positive cells (which include BG) alone, and both cell types showed less anxious behavior. Also, Gys1 deficiency in both cell types induced PC degeneration and ataxia. Our observations highlight a critical involvement of glycogen metabolism in both astrocytes and neurons for the normal function of the cerebellum.
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