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GDF-11 ELICITS POTENT ANALGESIA WITHOUT HYPERTHERMIC LIABILITY VIA THE FUNCTIONAL INHIBITION OF TRPV1 CHANNELS
Yong Ho Kimand 4 co-authors
Gachon University College of Medicine
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-446
Presentation
Date TBA
Board: PS01-07AM-446
Event Information
Poster Board
PS01-07AM-446
Poster
View posterAbstract
Hormonal changes during aging and their association with chronic pain prompted our investigation examining the effects of the aging-related growth differentiation factor-11 (GDF-11) on transient receptor potential vanilloid 1 (TRPV1) activity. Although TRPV1 has been widely studied as a major target for pain relief, its relationship with GDF-11 has not been thoroughly explored. In this study, we demonstrated that GDF-11 concentration-dependently inhibits capsaicin-induced TRPV1 activation in human dorsal root ganglion neurons, murine dorsal root ganglion neurons, and TRPV1-overexpressing HEK293 cells. Furthermore, behavioral studies revealed that GDF-11 alleviates capsaicin-induced pain responses and reduces thermal hyperalgesia in neuropathic pain models, without hyperthermia. Overall, our findings suggest that GDF-11 exerts its analgesic effects by inhibiting TRPV1, indicating its potential as a safe and effective therapeutic candidate for next-generation analgesics.
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