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THE IMPACT OF CA2 INHIBITION ON THE PREFRONTAL AND THALAMIC NETWORK
Alessa A. Franzand 3 co-authors
Boehringer Ingelheim Pharma GmbH & Co. KG
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS07-10AM-419
Presentation
Date TBA
Board: PS07-10AM-419
Event Information
Poster Board
PS07-10AM-419
Poster
View posterAbstract
Disturbances in the neuronal activity of the murine hippocampal CA2 subregion impair social memory, positioning CA2 as key hub of the social memory circuit. Both clinical and preclinical data implicate CA2 dysfunction in psychiatric disorders such as schizophrenia, underscoring the need to gain a deeper understanding of alterations within the underlying cognition circuit for the development of future therapeutic treatments.
To further characterise the downstream effects of CA2 inhibition, CA2 pyramidal neurons were acute and chronically inhibited using viral-mediated expression of Designer Receptors Exclusively Activated by Designer Drugs (DREADD). Whole brain functional ultrasound imaging on mice performed during early adulthood revealed that CA2 inhibition has consequences on the global network activity. Specifically, neuronal activity in the frontal network and also the thalamus was particularly vulnerable to perturbations in the neuronal activity of dorsal CA2 pyramidal neurons, highlighting a critical role for CA2 in coordinating distributed brain networks relevant to cognition.
To further characterise the downstream effects of CA2 inhibition, CA2 pyramidal neurons were acute and chronically inhibited using viral-mediated expression of Designer Receptors Exclusively Activated by Designer Drugs (DREADD). Whole brain functional ultrasound imaging on mice performed during early adulthood revealed that CA2 inhibition has consequences on the global network activity. Specifically, neuronal activity in the frontal network and also the thalamus was particularly vulnerable to perturbations in the neuronal activity of dorsal CA2 pyramidal neurons, highlighting a critical role for CA2 in coordinating distributed brain networks relevant to cognition.
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