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ePoster
IMPACT OF PHOSPHORYLATED TAU ON DENDRITIC AND AXONAL CALIBER OF HUMAN HIPPOCAMPAL PYRAMIDAL NEURONS
Lubna Morales de Pazand 7 co-authors
Centro de Neurociencias Cajal (CSIC)
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-394
Presentation
Date TBA
Board: PS02-07PM-394
Event Information
Poster Board
PS02-07PM-394
Poster
View posterAbstract
The neuropathological hallmarks of Alzheimer’s disease (AD) include amyloid plaques and intracellular neurofibrillary tangles caused by phosphorylated tau (pTau). Previous research from our group established that pTau presence triggers dendritic atrophy and synaptic loss. Here, we aim to further dissect the structural consequences of this pathology by analyzing the 3D structure of pyramidal neurons in the human hippocampal formation. Through intracellular Lucifer Yellow injections in fixed tissue, we performed a high-resolution morphometric analysis of dendritic and axonal arbors. Our results reveal that pTau+ pyramidal neurons exhibit a specific reduction in the diameter of both dendrites and axons, without significant changes in dendritic segment length. These structural alterations suggest that pTau accumulation compromises the cytoarchitecture of pyramidal cells, likely leading to specific functional deficits in connectivity and signal propagation within the hippocampal circuit.
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