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INVESTIGATION OF THE PREDICTABILITY OF DIAGNOSTIC STABILITY AND DISEASE COURSE IN FIRST-EPISODE PSYCHOSIS USING BRAIN MORPHOLOGY AND PERIPHERAL INFLAMMATORY MARKERS
Kübra Dikici Saraçoğluand 3 co-authors
University of Health Sciences, Basaksehir Cam and Sakura City Hospital
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-524
Presentation
Date TBA
Board: PS01-07AM-524
Event Information
Poster Board
PS01-07AM-524
Poster
View posterAbstract
This study aimed to investigate the predictive role of brain morphology and peripheral inflammatory markers on diagnostic stability and disease course in first-episode psychosis.A total of fifty-one patients hospitalized between September 2020 and October 2024 with complete MRI and blood sample datasets were included in the analysis.Peripheral inflammatory indices extracted from blood samples and T1-weighted MRI scans standardized using SynthSR, segmented using CAT12, and analyzed via voxel-based morphometry implemented in SPM12 were obtained from the time of hospitalization. At follow-up (mean 22.5±12.4 months), clinical evaluations included the SCID-5-CV, HAM-D, YMRS, BPRS, PANSS, and GAF, as well as validated instruments assessing resilience, childhood trauma, and chronic stress.Group comparisons and mediation analyses were performed.During follow-up, diagnoses within the schizophrenia spectrum, BD and MDD showed high diagnostic stability.Biomarker–clinical association analyses indicated that monocyte-weighted indices demonstrated stronger and more consistent correlations.The monocyte-to-lymphocyte ratio(MLR) was negatively correlated with BPRS and PANSS scores and positively correlated with GAF scores.Voxel-based morphometry analyses showed that the MDD group exhibited higher gray matter volume in the middle occipital gyrus, fusiform gyrus, anterior prefrontal cortex, pars opercularis, middle frontal gyrus compared to BD and other psychotic disorder groups.In addition, monocyte levels were positively associated with gray matter volume in the primary sensory cortex and posterior cerebellum, and negatively associated with the precuneus.Mediation analyses demonstrated that gray matter volume partially mediated the relationship between MLR and negative symptoms.These findings support a transdiagnostic model of psychosis, linking peripheral inflammation–brain morphology interactions to symptoms and functional outcomes.
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