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IRISIN AND EXTRACELLULAR VESICLE–ASSOCIATED BIOCHEMICAL MARKERS DEFINE THE SIGNATURE OF INTENSIVE PHYSICAL ACTIVITY IN PARKINSON’S DISEASE
Deborah Di Martinoand 14 co-authors
University of Pavia
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS06-09PM-641
Presentation
Date TBA
Board: PS06-09PM-641
Event Information
Poster Board
PS06-09PM-641
Poster
View posterAbstract
Physical exercise is gaining interest in Parkinson’s disease (PD) for its potential to improve motor and non-motor symptoms. Preclinical studies suggest that exercise increases BDNF levels and activates anti-inflammatory pathways. Irisin, a myokine released during exercise, may also exert neuroprotective effects. Exercise modulates the release and cargo of extracellular vesicles (EVs), potentially mediating its benefits. This study aims to investigate the role of EVs and irisin in physical activity and their potential as biomarkers.
PD patients were recruited into an active group (n=24), undergoing 3 months of high-intensity treadmill training, or a sedentary group (n=20). Plasma EVs were isolated and quantified. EV cargo (inflammatory markers, alpha-synuclein, and BDNF) was analyzed by Western blot and ELISA.
Plasma irisin was measured by ELISA in PD patients (sedentary n=30, endurance-trained n=15) and matched healthy controls (sedentary n=30, endurance-trained n=15).
At baseline, EV concentration correlated with UPDRS III (p = 0.016), MoCA (p = 0.04), and age (p = 0.041). Alpha-synuclein correlated with disease duration (p = 0.046). EV concentration, alpha-synuclein and BDNF did not change between baseline and follow-up. In the PD-active group, a negative correlation emerged between ∆EV concentration and disease duration (p = 0.0043).
Resting irisin levels were significantly lower in active versus sedentary patients (p = 0.003).
Preliminary data suggest biochemical correlations with both motor and cognitive features in PD, as well as an effect of exercise on irisin levels. Further analyses are ongoing.
This project was supported by European Union – Next Generation EU – PNRR M6C2 - 2.1 (PNRR-MAD-2022-12375804).
PD patients were recruited into an active group (n=24), undergoing 3 months of high-intensity treadmill training, or a sedentary group (n=20). Plasma EVs were isolated and quantified. EV cargo (inflammatory markers, alpha-synuclein, and BDNF) was analyzed by Western blot and ELISA.
Plasma irisin was measured by ELISA in PD patients (sedentary n=30, endurance-trained n=15) and matched healthy controls (sedentary n=30, endurance-trained n=15).
At baseline, EV concentration correlated with UPDRS III (p = 0.016), MoCA (p = 0.04), and age (p = 0.041). Alpha-synuclein correlated with disease duration (p = 0.046). EV concentration, alpha-synuclein and BDNF did not change between baseline and follow-up. In the PD-active group, a negative correlation emerged between ∆EV concentration and disease duration (p = 0.0043).
Resting irisin levels were significantly lower in active versus sedentary patients (p = 0.003).
Preliminary data suggest biochemical correlations with both motor and cognitive features in PD, as well as an effect of exercise on irisin levels. Further analyses are ongoing.
This project was supported by European Union – Next Generation EU – PNRR M6C2 - 2.1 (PNRR-MAD-2022-12375804).
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