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KNOCKDOWN OF NPY1 RECEPTOR AS A PRE-CLINICAL MODEL OF ADULT HIPPOCAMPAL NEUROGENESIS-LIKE PATHOLOGIES
Isabel Moreno Madridand 15 co-authors
Universidad de Málaga
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-280
Presentation
Date TBA
Board: PS02-07PM-280
Event Information
Poster Board
PS02-07PM-280
Poster
View posterAbstract
The Adult Hippocampal Neurogenesis (AHN) alteration has been seen to be in the basis of many symptoms in certain neurodegenerative and neuropsychiatric disorders such as Alzheimer`s Disease (AD) or Mayor Depressive Disorder (MDD). In previous research, we found that an increase in the formation of NPY1R-based heteroreceptor complexes within the dentate gyrus of the hippocampus leads to an enhanced neurogenesis and improved spatial memory performance, as well as a decrease of depressive-like behaviour. Consequently, the purpose of this work was studying the effect on the hippocampus of knockdown for NPY1R. For this, Acell SmartPool siRNA was administered intracerebroventricularly in Sprague-Dawley rats. The formation of NPY1R-based heteroreceptor complexes, immunoreactivity and behaviour were assessed 6, 8 and 10 days post-injection. The results interestingly show that whereas there is no neurogenesis, spatial memory or depressive-like impairment, there is a reduction on the number of NPY1R/GALR2 and NPY1R/TrkB heteroreceptor complexes formation in the hippocampus, as well as a reduced immunoreactivity for NPY1R. We conclude that, the NPY1R Knockdown model is effective to reproduce a transient disruption of NPY1R effect. However, no effects were observed on neurogenesis and behavioural but fails to affect both neurogenesis and behavioural suggested effect. Further investigation is required to elucidate if it could mark the transition from an early non clinical-stages to a full pathology-like stages in these diseases.
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