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LIGHT-INDUCED CONTROL OF HIPPO PATHWAY KINASE NDR2 TO INVESTIGATE ITS ROLE IN MECHANOTRANSDUCTION AND AGEING BRAIN
Zeynep Gizem Keskinand 2 co-authors
Otto-von-Guericke University Magdeburg
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS07-10AM-049
Presentation
Date TBA
Board: PS07-10AM-049
Event Information
Poster Board
PS07-10AM-049
Poster
View posterAbstract
Nuclear Dbf2-related kinases 2 (Ndr2) is the major Ndr kinase in the mouse brain and critically involved in integrin-mediated dendritic arborization and synaptic plasticity. We previously demonstrated that activation of Ndr2 occurs upon membrane recruitment and stimulates the endosomal recycling and inside-out activation of β1-integrins. To understand the involved cellular processes of Ndr2, we are developing new genetic systems for light activatable translocation of the Ndr2 to the plasma membrane with red light-sensitive Phy-PIF phytochrome systems and blue light-sensitive CRY2/CIBN systems as our optogenetic tools. Control experiments are conducted using light activated SOS2 to stimulate RAS/RAF/ERK pathway signaling, which confirmed the efficient plasma membrane recruitment and stimulation of ERK phosphorylation. Using live-cell imaging we investigate signaling pathways downstream of Ndr2 including RAF/MEK/ERK and PI3K/Akt/mTOR and their role in neuronal differentiation.
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