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ePoster
LITHIUM PROMOTES SUSTAINED ACTIVE COPING BEHAVIOR BY ATTENUATING NEURAL ACTIVITY OF THE LATERAL HABENULA
Haoyue Guoand 8 co-authors
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-533
Presentation
Date TBA
Board: PS02-07PM-533
Event Information
Poster Board
PS02-07PM-533
Poster
View posterAbstract
The missing layer of understanding how neural modulations (drugs and brain stimulation) change behavior is the gap between molecular/cellular activities and animal behaviors. Lithium is known to influence at least 10 types of ubiquitous molecules in the brain, however, how its molecular mechanisms explain its effective action in mood stabilizing and suicide prevention (the most recognized clinical effects) is still elusive. We applied neural activity recording in behaving animals and found lithium attenuated the activities of the lateral habenula which contributed to the prolonged active coping behavior indicating enhanced motivation of staying alive in response to despair.
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