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MANF-1 IS NECESSARY FOR MUSCLE MAINTENANCE AND FUNCTION IN C. ELEGANS
Shane Taylorand 4 co-authors
McMaster University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-215
Presentation
Date TBA
Board: PS04-08PM-215
Event Information
Poster Board
PS04-08PM-215
Poster
View posterAbstract
Age-related muscle decline is a prominent feature of aging, leading to reduced mobility and quality of life. While interventions such as exercise and genetic modulation of stress pathways can delay muscle deterioration, the molecular mechanisms that maintain muscle integrity throughout aging remain poorly understood. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a protein known for its neuroprotective properties. In Caenorhabditis elegans (C. elegans), MANF (manf-1) has been shown to protect against age-dependent protein aggregation, promote dopaminergic neuron survival, and extend lifespan. Our recent discovery that manf-1 is expressed in body wall muscles led us to investigate its potential role in skeletal muscles.
To study this, we are carrying out a combination of structural and behavioural experiments to examine muscle integrity and function in C. elegans strains with altered manf-1 function. Our data indicate that loss of manf-1 function causes defects in muscle function, whereas muscle performance is enhanced in animals overexpressing manf-1. These results are supported by transcriptome profiling studies, which reveal that MANF regulates genes involved in muscle maintenance and muscle function. Ongoing work aims to define the cellular and molecular mechanisms of MANF function in muscles. Together, these findings identify MANF as a novel regulator of muscle function in multicellular eukaryotes.
To study this, we are carrying out a combination of structural and behavioural experiments to examine muscle integrity and function in C. elegans strains with altered manf-1 function. Our data indicate that loss of manf-1 function causes defects in muscle function, whereas muscle performance is enhanced in animals overexpressing manf-1. These results are supported by transcriptome profiling studies, which reveal that MANF regulates genes involved in muscle maintenance and muscle function. Ongoing work aims to define the cellular and molecular mechanisms of MANF function in muscles. Together, these findings identify MANF as a novel regulator of muscle function in multicellular eukaryotes.
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