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MICROGLIA REGULATE THE NUMBER OF LAYER V NEURONS IMMEDIATELY AFTER BIRTH
Franz Markertand 5 co-authors
University Medical Center
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS06-09PM-308
Presentation
Date TBA
Board: PS06-09PM-308
Event Information
Poster Board
PS06-09PM-308
Poster
View posterAbstract
Microglia are known for secreting neurotrophic factors, such as IGF-1, essential for the survival of layer V neurons after the postnatal stage (P)3.5. However, they colonize the cortical plate around embryonic stage (E)17.5, and their perinatal function between these stages remains unclear. We administered PLX5622 from E17.5 onwards to specifically deplete microglia in the perinatal cortex. Microglia reduction led to enlarged cortices, an increase in layer V neurons, and an elevated number of synapses at P3.5, highlighting a perinatal phagocytic role of microglia. Between P3.5 and P5.5, microglia reduction led to a decrease in layer V neurons, while cortical volume and number of synapses remained elevated, revealing a functional switch to a specific neurotrophic role. Microglia-depleted pups showed an accelerated development of the righting reflex, possibly induced by the sustained elevated number of synapses. This study discovers the pivotal perinatal functions of microglia and their potential influence on motoric development.
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