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MULTIMODAL NON-PHARMACOLOGICAL INTERVENTIONS ATTENUATE TAU PROPAGATION IN R3M4 TAU TRANSGENIC MICE
Tomas Smolekand 3 co-authors
Institute of Neuroimmunology, SAS, v.v.i.
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-366
Presentation
Date TBA
Board: PS02-07PM-366
Event Information
Poster Board
PS02-07PM-366
Poster
View posterAbstract
The aim of this study was to investigate the mechanistic effects of multimodal non-pharmacological interventions on tau propagation and associated pathological processes in a preclinical mouse model of Alzheimer’s disease. R3m4 tau transgenic mice were inoculated with human tau isolates to induce tau propagation and subsequently subjected to a combined intervention consisting of environmental enrichment and dietary modulation. Neuropathological, molecular, and biochemical analyses were performed to assess tau pathology, neuroinflammatory responses, synaptic integrity, and alterations in energy metabolism. Multimodal non-pharmacological interventions significantly attenuated tau propagation and modulate neuroinflammation and homeostasis compared to control animals. These effects were accompanied by modulation of pathways implicated in synaptic plasticity, inflammatory signalling, and cellular energetics. Collectively, these findings demonstrate that combined lifestyle-related interventions effectively modulate tau-driven neurodegeneration and provide experimental support for multimodal non-pharmacological strategies in Alzheimer’s disease research.
Acknowledgement : This work was supported by JPND MULTI-MEMO, APVV -23-0420 and VEGA 2/0155/25 grants.
Acknowledgement : This work was supported by JPND MULTI-MEMO, APVV -23-0420 and VEGA 2/0155/25 grants.
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