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PATHWAY-DEPENDENT COUPLING OF RHYTHMIC ACTIVITY IN THE HIPPOCAMPUS DURING SLEEP-LIKE STATES
Mitchell Prostebbyand 1 co-author
Neuroscience and Mental Health Institute
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-684
Presentation
Date TBA
Board: PS05-09AM-684
Event Information
Poster Board
PS05-09AM-684
Poster
View posterAbstract
During sleep, rhythmic brain activity in the hippocampus (HPC) is known to play a critical role in the consolidation of memory. The organisation of low frequency (slow, theta) and high frequency (spindles, gamma, ripples) oscillations is thought to create different modes of information processing through the circuity of the HPC itself. By applying source separation techniques to multichannel recordings of the HPC in rats, we first demonstrate that low frequency activity in the HPC can be extracted into multiple generators arriving through anatomically-defined pathways. Applying the Better OSCillation wave detection algorithm (BOSC) reveals that a broader range of frequencies are coupled with these slower rhythms even within a given pathway. Moreover, we demonstrate that significant cross frequency coupling exists in both REM-like and NREM-like states with characteristics unique to each brain state. These findings help solidify a shift in our understanding of hippocampal processing from a set of distinct and limited frequencies carried by any one pathway to a more flexible, pathway-dependent form of processing which can involve multiple high frequency ranges and slow rhythmic generators contributing concurrently.
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