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PLASMON-ACTIVATED WATER REDUCES BLOOD-BRAIN BARRIER-CROSSING NANOPARTICLES CLUSTERING
Chia-Hsiung Chengand 2 co-authors
Taipei Medical University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-616
Presentation
Date TBA
Board: PS02-07PM-616
Event Information
Poster Board
PS02-07PM-616
Poster
View posterAbstract
Nanoparticles (NPs) are a powerful tool for targeted drug delivery, especially for crossing the blood-brain barrier (BBB), where pVEC peptides have proven effective for targeting. However, charged NPs may cluster with bloodstream proteins, presenting a significant risk and challenge. Plasmon-activated water (PAW), synthesized by exposing Au-coated ceramide to green light, exhibits small water clusters, a negative charge, and antioxidant activity. We found that negatively charged PAW in the bloodstream can bind to pVEC peptides coated on the surface of zein/γ-polyglutamic acid/low-molecular-weight chitosan (ZrLCP) NPs, which serve as a BBB-crossing carriers, and reduce their clustering with blood proteins in the mouse brain. These findings highlight the potential of PAW to reduce nanoparticle clustering in the bloodstream for clinical BBB-targeted nanodrug delivery.
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