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ePoster
A PONTINE CENTER ORCHESTRATES THE SPEED-ACCURACY TRADEOFF FOR ACTION AND FUNCTIONAL RECOVERY AFTER STRIATAL HEMORRHAGIC INJURY
Yunfan Zhangand 7 co-authors
Institute of Neuroscience (ION)/Chinese Academy of Sciences (CAS), Center for Excellence in Brain Science and Intelligence Technology
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS06-09PM-567
Presentation
Date TBA
Board: PS06-09PM-567
Event Information
Poster Board
PS06-09PM-567
Poster
View posterAbstract
Successful interaction with the environment relies on the ability to execute rapid and precise movements. Although a fundamental tradeoff exists between speed and accuracy, the neural mechanisms that regulate this balance remain poorly understood. Here, we identified a population of neurons in the pons that exhibit task-related activity during precision-demanding motor behaviors. Using chemogenetic and closed-loop optogenetic manipulations, we demonstrate that activation of these neurons enhances movement accuracy at the expense of speed in a skilled forelimb single-pellet reaching task, whereas their inhibition disrupts task execution. Further circuit analyses revealed that pontine neurons integrate striatal inputs to selectively modulate precision-demanding motor control. Notably, activating these neurons ameliorates motor deficits after striatal hemorrhagic injury. In summary, these findings identify a pontine circuit that integrates striatal inputs to regulate the speed-accuracy tradeoff in motor control and highlight a potential target for restoring motor precision after striatal injury.
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