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PRELIMINARY FINDINGS ON SEX DIFFERENCES IN ABNORMAL TAU PROTEIN PHOSPHORYLATION IN ALZHEIMER´S DISEASE PATIENTS
Sergio Plaza-Alonsoand 4 co-authors
Centro de Neurociencias Cajal (CSIC)
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-378
Presentation
Date TBA
Board: PS02-07PM-378
Event Information
Poster Board
PS02-07PM-378
Poster
View posterAbstract
At the moment, no efficient treatments are available to prevent or cure Alzheimer´s disease (AD). Treatments targeting the main pathological hallmarks have been mostly unsuccessful, highlighting the clear need for new and more effective therapeutic approaches. In this regard, recent studies suggest a lack of sex-specific perspective in AD research despite evidence that women often show a reduced therapeutic response compared to men. In this preliminary study, we investigated whether sex differences might influence the intraneuronal accumulation of abnormally phosphorylated Tau protein (pTau). Using immunohistochemical and imaging analysis techniques, we conducted an initial assessment of the presence and distribution of pTau-positive neurons (labeled by pS396 and AT100 antibodies) in the CA1 region of human brain tissue from non-demented and AD cases.
Our preliminary data show a higher density of pS396-positive neurons in women, while no significant differences were observed between sexes for AT100-positive neurons. Although these results require validation in larger cohorts, they suggest that including a sex-specific perspective is crucial to advance our knowledge of AD and develop more effective therapies.
Our preliminary data show a higher density of pS396-positive neurons in women, while no significant differences were observed between sexes for AT100-positive neurons. Although these results require validation in larger cohorts, they suggest that including a sex-specific perspective is crucial to advance our knowledge of AD and develop more effective therapies.
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