Poster preview
ePoster
REFINING DETECTION OF SUBCLINICAL EPILEPTIFORM ACTIVITY IN ALZHEIMER'S DISEASE: A CASE-CONTROL STUDY AND CALL FOR A CONSENSUS
Anna B. Szaboand 5 co-authors
Université de Toulouse
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-103
Presentation
Date TBA
Board: PS05-09AM-103
Event Information
Poster Board
PS05-09AM-103
Poster
View posterAbstract
Sleep-predominant network hyperexcitability is increasingly recognized as a potential disease-accelerating comorbidity in Alzheimer's disease (AD). However, its prevalence and risk-factors remain debated, largely due to cohort-specific and methodological differences across studies.
In this prospective case-control study, we investigated potential ways of improving detection, from translational approaches focusing on REM-sleep to refined EEG setups and added clinical questionnaires. We recruited 30 early-stage AD patients without a history of epilepsy and 30 age-matched controls. Participants underwent overnight polysomnography with video-EEG.
Interictal epileptic discharges (IEDs) were detected in three patients (10%) and one control (3.33%), a difference not reaching statistical significance (p =.612). Most events occurred during NREM sleep. Eight patients (26.67%) reported symptoms compatible with epileptic seizures - one of whom also presented with IEDs. Patients with IEDs or reported symptoms suggestive of potential seizures exhibited more severe sleep-disordered breathing and reduced precuneus volume compared to those without.
Despite efforts to optimize detection accuracy, our findings reveal a lower-than-expected percentage of AD patients with IEDs, yet support previous findings suggesting that sleep-disordered breathing and specific atrophy patterns could flag at-risk patients, guiding screening in clinical settings. Our findings also favour validation efforts of questionnaires to support the diagnostic process.
In this prospective case-control study, we investigated potential ways of improving detection, from translational approaches focusing on REM-sleep to refined EEG setups and added clinical questionnaires. We recruited 30 early-stage AD patients without a history of epilepsy and 30 age-matched controls. Participants underwent overnight polysomnography with video-EEG.
Interictal epileptic discharges (IEDs) were detected in three patients (10%) and one control (3.33%), a difference not reaching statistical significance (p =.612). Most events occurred during NREM sleep. Eight patients (26.67%) reported symptoms compatible with epileptic seizures - one of whom also presented with IEDs. Patients with IEDs or reported symptoms suggestive of potential seizures exhibited more severe sleep-disordered breathing and reduced precuneus volume compared to those without.
Despite efforts to optimize detection accuracy, our findings reveal a lower-than-expected percentage of AD patients with IEDs, yet support previous findings suggesting that sleep-disordered breathing and specific atrophy patterns could flag at-risk patients, guiding screening in clinical settings. Our findings also favour validation efforts of questionnaires to support the diagnostic process.
Recommended posters
SLEEP FRAGMENTATION DIFFERENTIALLY ALTERS HIPPOCAMPAL NETWORK DYNAMICS AND MEMORY IN WILD-TYPE AND APP-PS1 MICE
Giulia Rigamonti, Francisco J. Molina Paya, Giselda Cabral Pereira, Irene Gascon Lopez, Manuel Tirado, Pablo Abad Perez, Jorge R. Brotons Mas, Jose V. Sanchez Mut
LATENT-TRAJECTORY MODELING OF LONGITUDINAL EEG ALTERATIONS IN PRODROMAL Α-SYNUCLEINOPATHIES
Chiara Scotto, Monica Roascio, Dario Arnaldi, Matteo Pardini, Pietro Mattioli, Beatrice Orso, Francesco Famà, Laura Giorgetti, Ki-Young Jung, Jung-Ick Byun, Federico Barban, Gabriele Arnulfo
THALAMOCORTICAL CONNECTIVITY AND SLEEP DISRUPTION IN ALZHEIMER'S DISEASE: CORRELATIONS WITH COGNITIVE DEFICITS
Carla Burnet-Merlin, Audrey Hay, Aurélie Brécier
RESTING-STATE EEG MARKERS OF CORTICAL SLOWING AND EXPLORATORY PROBIOTIC EFFECTS IN MILD ALZHEIMER’S DISEASE
Benson Botchway, Ioanna Kousiappa, Andreas Koupparis, Savvas Papacostas, Aleksandar Jovanovic, Stelios Georgiades, Stavros Bashiardes, Andreas Hadjisavvas, George Loucaides, Archontia Adamou, Yiolanda Christou, Mihalis Panagiotidis, Nicoletta Nicolaou
RESTING-STATE EEG SIGNATURES OF ABNORMAL COGNITION AND PLASMA MARKERS OF PATHOLOGICAL AGING IN MIDDLE-AGED ADULTS
Natalia Castillo Dutor, Ruben Perellón-Alfonso, Gabriele Cattaneo, Javier Solana-Sánchez, David Bartrés-Faz, J M Tormos-Muñoz, Mouhsin M Shafi, Álvaro Pascual-Leone, Recep A Ozdemir
EXPLORING NORADRENERGIC SIGNALING AND SLEEP PATTERNS IN PRODROMAL STAGES OF ALZHEIMER’S DISEASE MOUSE MODELS
Paola Milanese, Laura M.J. Fernandez, Georgios Foustoukos, Lila Banterle, Matthias Prigge, Anita Lüthi