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REMODELING OF CORTICAL NEURONAL NETWORKS BY GLIAL CELLS FOLLOWING BRAIN INJURY
Jonas Benzand 2 co-authors
CECAD
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS03-08AM-154
Presentation
Date TBA
Board: PS03-08AM-154
Event Information
Poster Board
PS03-08AM-154
Poster
View posterAbstract
Emerging evidence indicates that focal brain injury leads to widespread reorganization of neuronal networks, including regions distant from the primary lesion. On the other hand, involvement of glial cells as drivers of changes in connectivity during development is well described, however their potential to drive changes also during adulthood or states of injury is less known. In previous work we investigated microglial and astrocytic reactivity states in the cortical stab wound injury (SW) mouse model, establishing a temporal profile of inflammation driven by these cells at the injury site. We now broadened our analysis to how changes in local and long-range projections to injured neurons may be modulated by glial cell inflammatory activity. To map connectivity changes at the single cell level, we use a modified rabies transsynaptic tracing system at multiple timepoints after SW. Tracing data is analyzed by semi-automated QUINT analysis in the 3D Allen Brain Atlas. Complementary pharmacological and genetic manipulation of microglia and astrocytes is used to causally identify drivers of maladaptive connectivity changes or facilitators of brain circuit repair.
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