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ePoster
RESTORING EXCITATORY/INHIBITORY (E/I) BALANCE TO AMELIORATE AUTISM SPECTRUM DISORDER (ASD)–LIKE BEHAVIORS IN MOUSE MODELS
Mihyun Baeand 1 co-author
IBS
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-291
Presentation
Date TBA
Board: PS02-07PM-291
Event Information
Poster Board
PS02-07PM-291
Poster
View posterAbstract
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with diverse etiologies, and the heterogeneous nature of disease presentation and risk genes have made treatment especially difficult. Fortunately, excitatory/inhibitory (E/I) imbalance in neural circuits has emerged as a convergent pathophysiological mechanism. In this study, we investigated therapeutic strategies aimed at restoring E/I balance in genetically validated mouse models of ASD. Through a combination of pharmacological and/or genetic interventions, we modulated inhibitory tone and excitatory drive. Behavioral assays revealed significant improvements in core ASD-like phenotypes, including social interaction deficits and repetitive behaviors, following treatment. Electrophysiological recordings confirmed a normalization of synaptic activity toward physiological E/I ratios. Our findings highlight the therapeutic potential of targeting E/I imbalance as a unifying mechanism in ASD and provide a translational framework for future clinical intervention strategies.
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